F7129
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F7129
Sigma
5-Fluorocytosine
| Synonym: | 4-amino-5-fluoro-2(1H)-pyrimidinone, Flucytosine |
| CAS Number: | 2022-85-7 |
| Linear Formula: | C4H4FN3O |
| Molecular Weight: | 129.09 |
| Beilstein Registry Number: | 127285 |
| EC Number: | 217-968-7 |
| MDL number: | MFCD00006035 |
| PubChem Substance ID: | 24894928 |
Description
| Biochem/physiol Actions | Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis. |
Properties
| mp | 298-300 °C (dec.)(lit.) |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | HA6040000 |
References
| reference | Waldorf, A.R., and Polak, A., Mechanisms of action of 5-fluorocytosine. Antimicrob. Agents Chemother. 23, 79-85, (1983) |
| Diasio, R.B., et al., Mode of action of 5-fluorocytosine. Biochem. Pharmacol. 27, 703-7, (1978) | |
| Merck | Merck 13,4151 |
| Beilstein | Beil. 25,IV,3688 |
| Aldrich MSDS 1, 959:D / Corp MSDS 1 (1), 1705:D / FT-NMR 1 (3), 383:C / RegBook 1 (2), 2579:B / Sax 6, 1435 / Sigma FT-IR 1 (1), 996:A / Structure Index 1, 408:C:1 |
